Flow cytometric analysis of CD123 is useful for immunophenotyping classical Hodgkin lymphoma
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منابع مشابه
Flow cytometric analysis of CD123 is useful for immunophenotyping classical Hodgkin lymphoma.
Although the diagnosis of classical Hodgkin lymphoma (CHL) is traditionally made morphologically in tissue sections, it is now possible to diagnose CHL by flow cytometry (FC). In an effort to identify additional antigens on Hodgkin and Reed-Sternberg (HRS) cells that might be useful for immunophenotyping this lymphoma by FC, we examined the expression of CD123 (α chain of the IL-3R) on HRS cell...
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Am J Clin Pathol 2011;136:156-158 157 © American Society for Clinical Pathology high-fluorescence nucleated cells that may appear in CSF under certain conditions (eg, neoplasms or leptomeningeal metastases, macrophages, and eosinophils). These conclusions are similar to those drawn by other authors4 who have found most patients with low cell counts (<20/μL) to be correctly classified. Obviously...
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OBJECTIVES We have recently demonstrated that classical Hodgkin lymphoma (CHL) can be immunophenotyped by flow cytometry (FC), thus obviating the need for immunohistochemistry in many cases. The previously described nine-color assay, however, cannot be used by laboratories that do not have access to a nine- or ten-color flow cytometer. Therefore, a six-color FC tube was designed employing the f...
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Classical Hodgkin lymphoma (CHL) is a relatively uncommon B cell-derived neoplasm that presents with rare malignant cells in an abundant reactive background. The diagnosis of CHL currently relies on a combination of morphologic findings and immunohistochemical stains. With the exception of rare cases with dramatically increased malignant populations, isolation of pure viable tumor cells has not...
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Flow cytometric immunophenotyping remains an indispensable tool for the diagnosis, classification, staging, and monitoring of hematologic neoplasms. The last 10 years have seen advances in flow cytometry instrumentation and availability of an expanded range of antibodies and fluorochromes that have improved our ability to identify different normal cell populations and recognize phenotypic aberr...
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ژورنال
عنوان ژورنال: Cytometry Part B: Clinical Cytometry
سال: 2010
ISSN: 1552-4949
DOI: 10.1002/cyto.b.20561